User profiles for V. G. Magupalli

Venkat Giri Magupalli

Lindsley F. Kimball Research Institute / New York Blood Center Enterprise
Verified email at nybc.org
Cited by 6276

SMOCs: supramolecular organizing centres that control innate immunity

JC Kagan, VG Magupalli, H Wu - Nature Reviews Immunology, 2014 - nature.com
The diverse receptor families of the innate immune system activate signal transduction
pathways that are important for host defence, but common themes to explain the operation of …

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

X Liu, Z Zhang, J Ruan, Y Pan, VG Magupalli, H Wu… - Nature, 2016 - nature.com
Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial
infection and danger signals. When activated, they cleave mouse and human gasdermin D (…

[HTML][HTML] Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes

A Lu, VG Magupalli, J Ruan, Q Yin, MK Atianand… - Cell, 2014 - cell.com
Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation
and cell death. AIM2 and NLRP3 are representative sensor proteins in two major families …

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

…, Y Bai, J Wang, LR Hollingsworth, VG Magupalli… - Nature …, 2020 - nature.com
Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells
assembles large complexes called inflammasomes, which activate inflammatory caspases to …

Gasdermin D pore structure reveals preferential release of mature interleukin-1

S Xia, Z Zhang, VG Magupalli, JL Pablo, Y Dong… - Nature, 2021 - nature.com
As organelles of the innate immune system, inflammasomes activate caspase-1 and other
inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive …

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

H Sharif, L Wang, WL Wang, VG Magupalli, L Andreeva… - Nature, 2019 - nature.com
The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid crystals,
amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the assembly …

Cryo-EM structures of the active NLRP3 inflammasome disc

L Xiao, VG Magupalli, H Wu - Nature, 2023 - nature.com
Inflammasomes are cytosolic innate immune complexes that activate caspase-1 following
detection of pathogenic and endogenous dangers 1 , 2 , 3 , 4 – 5 , and NACHT-, leucine-rich …

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

VG Magupalli, R Negro, Y Tian, AV Hauenstein… - Science, 2020 - science.org
… The main aim of the manuscript by Magupalli et al. (1) was to identify the location and
mechanism of NLRP3 inflammasome speck formation. The authors introduced their work by stating …

[HTML][HTML] NLRP3 inflammasome assembly in neutrophils is supported by PAD4 and promotes NETosis under sterile conditions

…, S Gutch, N Sorvillo, L Shi, VG Magupalli… - Frontiers in …, 2021 - frontiersin.org
Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing
3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human …

Multiple RIBEYE–RIBEYE interactions create a dynamic scaffold for the formation of synaptic ribbons

VG Magupalli, K Schwarz, K Alpadi… - Journal of …, 2008 - Soc Neuroscience
Synaptic ribbons are large, dynamic structures in the active zone complex of ribbon synapses
and important for the physiological properties of these tonically active synapses. RIBEYE …