User profiles for V. G. Magupalli
Venkat Giri MagupalliLindsley F. Kimball Research Institute / New York Blood Center Enterprise Verified email at nybc.org Cited by 6276 |
SMOCs: supramolecular organizing centres that control innate immunity
The diverse receptor families of the innate immune system activate signal transduction
pathways that are important for host defence, but common themes to explain the operation of …
pathways that are important for host defence, but common themes to explain the operation of …
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial
infection and danger signals. When activated, they cleave mouse and human gasdermin D (…
infection and danger signals. When activated, they cleave mouse and human gasdermin D (…
[HTML][HTML] Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation
and cell death. AIM2 and NLRP3 are representative sensor proteins in two major families …
and cell death. AIM2 and NLRP3 are representative sensor proteins in two major families …
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
…, Y Bai, J Wang, LR Hollingsworth, VG Magupalli… - Nature …, 2020 - nature.com
Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells
assembles large complexes called inflammasomes, which activate inflammatory caspases to …
assembles large complexes called inflammasomes, which activate inflammatory caspases to …
Gasdermin D pore structure reveals preferential release of mature interleukin-1
As organelles of the innate immune system, inflammasomes activate caspase-1 and other
inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive …
inflammatory caspases that cleave gasdermin D (GSDMD). Caspase-1 also cleaves inactive …
Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome
The NLRP3 inflammasome can be activated by stimuli that include nigericin, uric acid crystals,
amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the assembly …
amyloid-β fibrils and extracellular ATP. The mitotic kinase NEK7 licenses the assembly …
Cryo-EM structures of the active NLRP3 inflammasome disc
Inflammasomes are cytosolic innate immune complexes that activate caspase-1 following
detection of pathogenic and endogenous dangers 1 , 2 , 3 , 4 – 5 , and NACHT-, leucine-rich …
detection of pathogenic and endogenous dangers 1 , 2 , 3 , 4 – 5 , and NACHT-, leucine-rich …
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
VG Magupalli, R Negro, Y Tian, AV Hauenstein… - Science, 2020 - science.org
… The main aim of the manuscript by Magupalli et al. (1) was to identify the location and
mechanism of NLRP3 inflammasome speck formation. The authors introduced their work by stating …
mechanism of NLRP3 inflammasome speck formation. The authors introduced their work by stating …
[HTML][HTML] NLRP3 inflammasome assembly in neutrophils is supported by PAD4 and promotes NETosis under sterile conditions
…, S Gutch, N Sorvillo, L Shi, VG Magupalli… - Frontiers in …, 2021 - frontiersin.org
Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing
3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human …
3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human …
Multiple RIBEYE–RIBEYE interactions create a dynamic scaffold for the formation of synaptic ribbons
VG Magupalli, K Schwarz, K Alpadi… - Journal of …, 2008 - Soc Neuroscience
Synaptic ribbons are large, dynamic structures in the active zone complex of ribbon synapses
and important for the physiological properties of these tonically active synapses. RIBEYE …
and important for the physiological properties of these tonically active synapses. RIBEYE …