Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats

…, ML Logrip, C Rivier, V Repunte-Canonigo… - Journal of …, 2012 - Soc Neuroscience
Alcoholism is characterized by a compulsion to seek and ingest alcohol, loss of control over
intake, and the emergence of a negative emotional state during abstinence. We …

Design and characterization of a DNA‐encoded, voltage‐sensitive fluorescent protein

R Sakai, V RepunteCanonigo, CD Raj… - European Journal of …, 2001 - Wiley Online Library
Optical imaging of electrical activity has been suggested as a promising approach to
investigate the multineuronal representation of information processing in brain tissue. While …

VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation

…, E Crawford, P Koebel, V Repunte-Canonigo… - Nature …, 2014 - nature.com
Dopaminergic neurons in the ventral tegmental area (VTA) are well known for mediating the
positive reinforcing effects of drugs of abuse. Here we identify in rodents and humans a …

Gene expression evidence for remodeling of lateral hypothalamic circuitry in cocaine addiction

…, GF Koob, V Repunte-Canonigo… - Proceedings of the …, 2005 - National Acad Sciences
By using high-density oligonucleotide arrays, we profiled gene expression in reward-related
brain regions of rats that developed escalated cocaine intake after extended access to …

Viral vector-induced amygdala NPY overexpression reverses increased alcohol intake caused by repeated deprivations in Wistar rats

A Thorsell, V Repunte-Canonigo, LE O'Dell, SA Chen… - Brain, 2007 - academic.oup.com
Acute administration of neuropeptide Y (NPY) modulates alcohol intake in genetic and
chemical models of high intake, while leaving intake unaffected during ‘normal’ or baseline …

Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis

…, F Berton, V Repunte-Canonigo… - Journal of …, 2009 - Soc Neuroscience
The juxtacapsular bed nucleus of the stria terminalis (jcBNST) is activated in response to
basolateral amygdala (BLA) inputs through the stria terminalis and projects back to the anterior …

[HTML][HTML] Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats

V Repunte-Canonigo, C Lefebvre, O George… - Molecular …, 2014 - Springer
Background A thorough investigation of the neurobiology of HIV-induced neuronal dysfunction
and its evolving phenotype in the setting of viral suppression has been limited by the lack …

Corticosteroid sensitization drives opioid addiction

…, J Miranda-Barrientos, V Repunte-Canonigo… - Molecular …, 2022 - nature.com
The global crisis of opioid overdose fatalities has led to an urgent search to discover the
neurobiological mechanisms of opioid use disorder (OUD). A driving force for OUD is the …

[HTML][HTML] Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks

V Repunte-Canonigo, W Shin, LF Vendruscolo… - Genome biology, 2015 - Springer
Background A systems biology approach based on the assembly and interrogation of gene
regulatory networks, or interactomes, was used to study neuroadaptation processes …

[HTML][HTML] Gene expression patterns associated with neurological disease in human HIV infection

PP Sanna, V Repunte-Canonigo, E Masliah… - PLoS …, 2017 - journals.plos.org
The pathogenesis and nosology of HIV-associated neurological disease (HAND) remain
incompletely understood. Here, to provide new insight into the molecular events leading to …