Advanced neurotechnologies for chronic neural interfaces: new horizons and clinical opportunities
… 1D) (Seymour and Kipke, 2007), materials (Ludwig et al., 2006; Abidian and Martin, 2008),
approaches to mitigate chronic reactive tissue responses (Shain et al., 2003; Spataro et al., …
approaches to mitigate chronic reactive tissue responses (Shain et al., 2003; Spataro et al., …
Brain responses to micro-machined silicon devices
…, M Isaacson, HG Craighead, JN Turner, W Shain - Brain research, 2003 - Elsevier
Micro-machined neural prosthetic devices can be designed and fabricated to permit recording
and stimulation of specific sites in the nervous system. Unfortunately, the long-term use of …
and stimulation of specific sites in the nervous system. Unfortunately, the long-term use of …
Cerebral astrocyte response to micromachined silicon implants
JN Turner, W Shain, DH Szarowski, M Andersen… - Experimental …, 1999 - Elsevier
The treatment of neurologic disorders and the restoration of lost function due to trauma by
neuroprosthetic devices has been pursued for over 20 years. The methodology for fabricating …
neuroprosthetic devices has been pursued for over 20 years. The methodology for fabricating …
Whole animal perfusion fixation for rodents
The goal of fixation is to rapidly and uniformly preserve tissue in a life-like state. While placing
tissue directly in fixative works well for small pieces of tissue, larger specimens like the …
tissue directly in fixative works well for small pieces of tissue, larger specimens like the …
Complex impedance spectroscopy for monitoring tissue responses to inserted neural implants
…, JA Hippensteel, J Dilgen, W Shain… - Journal of neural …, 2007 - iopscience.iop.org
… Ischemic brain edema Stroke 11 593–601 Spataro L, Dilgen J, Retterer S, Spence AJ, Isaacson
M, Turner JN and Shain W 2005 Dexamethasone treatment reduces astroglia responses …
M, Turner JN and Shain W 2005 Dexamethasone treatment reduces astroglia responses …
Effects of insertion conditions on tissue strain and vascular damage during neuroprosthetic device insertion
Long-term integration of neuroprosthetic devices is challenged by reactive responses that
compromise the brain–device interface. The contribution of physical insertion parameters to …
compromise the brain–device interface. The contribution of physical insertion parameters to …
Patterned protein layers on solid substrates by thin stamp microcontact printing
…, HG Craighead, M Isaacson, JN Turner, W Shain - Langmuir, 1998 - ACS Publications
Microcontact printing (μCP) is a new method of molecularly patterning surfaces on a
micrometer scale. In this paper, we present the extension of microcontact printing to producing …
micrometer scale. In this paper, we present the extension of microcontact printing to producing …
Dexamethasone treatment reduces astroglia responses to inserted neuroprosthetic devices in rat neocortex
…, AJ Spence, M Isaacson, JN Turner, W Shain - Experimental …, 2005 - Elsevier
Microfabricated neural prosthetic devices hold great potential for increasing knowledge of
brain function and treating patients with lost CNS function. Time-dependent loss of brain-…
brain function and treating patients with lost CNS function. Time-dependent loss of brain-…
Controlling cellular reactive responses around neural prosthetic devices using peripheral and local intervention strategies
W Shain, L Spataro, J Dilgen… - IEEE transactions on …, 2003 - ieeexplore.ieee.org
… Isaacson, HG Craighead, JN Turner, and W. Shain, “Brain responses to micromachined
silicon devices,” Brain Res., to be published. [10] DJ Edell, VV Toi, VM McNeil, and LD Clark, “…
silicon devices,” Brain Res., to be published. [10] DJ Edell, VV Toi, VM McNeil, and LD Clark, “…
Topographically modified surfaces affect orientation and growth of hippocampal neurons
…, B Roysam, JN Turner, W Shain - Journal of neural …, 2004 - iopscience.iop.org
Extracellular matrix molecules provide biochemical and topographical cues that influence
cell growth in vivo and in vitro. Effects of topographical cues on hippocampal neuron growth …
cell growth in vivo and in vitro. Effects of topographical cues on hippocampal neuron growth …