Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities

WE Lyons, LA Mamounas… - Proceedings of the …, 1999 - National Acad Sciences
Brain-derived neurotrophic factor (BDNF) has trophic effects on serotonergic (5-HT) neurons
in the central nervous system. However, the role of endogenous BDNF in the development …

BDNF promotes the regenerative sprouting, but not survival, of injured serotonergic axons in the adult rat brain

…, DR Kaplan, L Tessarollo, WE Lyons - Journal of …, 2000 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) has trophic effects on serotonergic (5-HT) neurons
in the adult brain and can prevent the severe loss of cortical 5-HT axons caused by the …

Immunosuppressant FK506 promotes neurite outgrowth in cultures of PC12 cells and sensory ganglia.

WE Lyons, EB George, TM Dawson… - Proceedings of the …, 1994 - National Acad Sciences
The immunosuppressant drug FK506 acts by binding to receptor proteins, FK506-binding
proteins (FKBPs), which in turn can bind to and regulate a Ca(2+)-dependent phosphatase, …

Mutant SOD1 causes motor neuron disease independent of copper chaperone–mediated copper loading

JR Subramaniam, WE Lyons, J Liu, TB Bartnikas… - Nature …, 2002 - nature.com
Copper-mediated oxidative damage is proposed to play a critical role in the pathogenesis of
Cu/Zn superoxide dismutase (SOD1)–linked familial amyotrophic lateral sclerosis (FALS). …

Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning

IYC Liu, WE Lyons, LA Mamounas… - Journal of …, 2004 - Soc Neuroscience
In this study, brain-derived neurotrophic factor (BDNF) heterozygous knock-outs were tested
on fear conditioning, and their wild-type littermates were used as controls. Results showed …

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer's disease

…, DR Borchelt, L Mamounas, WE Lyons… - Journal of …, 2008 - Soc Neuroscience
β-Amyloid (Aβ) pathology is an essential pathogenic component in Alzheimer's disease (AD).
However, the significance of Aβ pathology, including Aβ deposits/oligomers and glial …

… the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter …

…, TA Mathews, L Tessarollo, WE Lyons… - Journal of neuroscience …, 2004 - Elsevier
Serotonin (5-HT) has been proposed to promote neuronal plasticity during the treatment of
mood and anxiety disorders and following neurodegenerative insult by altering the …

Neuronal regeneration enhances the expression of the immunophilin FKBP-12

WE Lyons, JP Steiner, SH Snyder… - Journal of …, 1995 - Soc Neuroscience
Immunophilins are a group of proteins that serve as receptors for the immunosuppressant
drugs cyclosporin A and FK506. The immunophilin designated FK-506 binding protein-12 (…

Anterograde transport of endogenous brain-derived neurotrophic factor in hippocampal mossy fibers

MA Smith, LX Zhang, WE Lyons, LA Mamounas - Neuroreport, 1997 - journals.lww.com
NEUROTROPHIC factors such as brain-derived neurotrophic factor (BDNF) are assumed to
provide trophic support via a target-derived, retrograde mechanism of action. However, …

Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling

J Müller, AM Cacace, WE Lyons, CB McGill… - … and cellular biology, 2000 - Taylor & Francis
Kinase suppressor of Ras (KSR) is an evolutionarily conserved component of Ras-dependent
signaling pathways. Here, we report the identification of B-KSR1, a novel splice variant of …