Stem cells reside in specialized microenvironments or 'niches' that regulate their function. In
vitro studies using hypoxic culture conditions (< 5% O 2 ) have revealed strong regulatory …

Lithium is widely used to treat bipolar disorder, but its mechanism of action in this disorder is
unknown. Several molecular targets of lithium have been identified, but these putative …

Lithium is widely used to treat bipolar disorder, but its mechanism of action in this disorder is
unknown. Lithium directly inhibits glycogen synthase kinase-3 (GSK3), a critical regulator of …

Hematopoietic stem cell (HSC) homeostasis depends on the balance between self renewal
and lineage commitment, but what regulates this decision is not well understood. Using loss-…

Lithium is the first-line therapy for bipolar disorder. However, its therapeutic target remains
controversial. Candidates include inositol monophosphatases, glycogen synthase kinase-3 (…

Classifying behavior patterns in mouse models of neurological, psychiatric and neurodevelopmental
disorders is critical for understanding disease causality and treatment. However, …

Fifty-two plant species, covering some Gymnosperms and all the key groups of Angiosperms,
were chosen for surveying their intrinsic beta-glucuronidase-like activities. Histochemical (…

Behavioral neuroscience research incorporates the identical high level of meticulous
methodologies and exacting attention to detail as all other scientific disciplines. To achieve …

Sleep disturbances and hyperactivity are prevalent in several neurodevelopmental disorders,
including autism spectrum disorders (ASDs) and attention deficit‐hyperactivity disorder (…

The regulation of behavior by the molecular components of the circadian clock is not well
understood. Here we report that mice lacking the nuclear receptor Rev-erbα, a potent …