Pincher, a pinocytic chaperone for nerve growth factor/TrkA signaling endosomes

Y Shao, W Akmentin, JJ Toledo-Aral… - The Journal of cell …, 2002 - rupress.org
Acentral tenet of nerve growth factor (NGF) action that is poorly understood is its ability to
mediate cytoplasmic signaling, through its receptor TrkA, that is initiated at the nerve terminal …

Acute destruction of the synaptic ribbon reveals a role for the ribbon in vesicle priming

…, B Mehta, N Babai, TM Bartoletti, W Akmentin… - Nature …, 2011 - nature.com
In vision, balance and hearing, sensory receptor cells translate sensory stimuli into electrical
signals whose amplitude is graded with stimulus intensity. The output synapses of these …

Pincher-mediated macroendocytosis underlies retrograde signaling by neurotrophin receptors

G Valdez, W Akmentin, P Philippidou… - Journal of …, 2005 - Soc Neuroscience
Retrograde signaling by neurotrophins is crucial for regulating neuronal phenotype and
survival. The mechanism responsible for retrograde signaling has been elusive, because the …

Scavenger receptor BI (SR-BI) clustered on microvillar extensions suggests that this plasma membrane domain is a way station for cholesterol trafficking between cells …

Y Peng, W Akmentin, MA Connelly… - Molecular biology of …, 2004 - Am Soc Cell Biol
Receptor-mediated trafficking of cholesterol between lipoproteins and cells is a
fundamental biological process at the organismal and cellular levels. In contrast to the well-studied …

Trk-signaling endosomes are generated by Rac-dependent macroendocytosis

…, J Rosenbaum, W Akmentin… - Proceedings of the …, 2007 - National Acad Sciences
Why neurotrophins and their Trk receptors promote neuronal differentiation and survival
whereas receptor tyrosine kinases for other growth factors, such as EGF, do not, has been a long…

Trk retrograde signaling requires persistent, Pincher-directed endosomes

P Philippidou, G Valdez, W Akmentin… - Proceedings of the …, 2011 - National Acad Sciences
Target-derived neurotrophins use retrogradely transported Trk-signaling endosomes to
promote survival and neuronal phenotype at the soma. Despite their critical role in neurotrophin …

Nanoscale dynamics of synaptic vesicle trafficking and fusion at the presynaptic active zone

T Vaithianathan, D Henry, W Akmentin, G Matthews - Elife, 2016 - elifesciences.org
10.7554/eLife.13245.001 The cytomatrix at the active zone (CAZ) is a macromolecular complex
that facilitates the supply of release-ready synaptic vesicles to support neurotransmitter …

Functional roles of complexin in neurotransmitter release at ribbon synapses of mouse retinal bipolar neurons

T Vaithianathan, D Henry, W Akmentin… - Journal of …, 2015 - Soc Neuroscience
Ribbon synapses of photoreceptor cells and bipolar neurons in the retina signal graded
changes in light intensity via sustained release of neurotransmitter. One molecular …

[HTML][HTML] Axonal α7* nicotinic acetylcholine receptors modulate glutamatergic signaling and synaptic vesicle organization in ventral hippocampal projections

C Zhong, W Akmentin, LW Role… - Frontiers in Neural …, 2022 - frontiersin.org
Modulation of the release of glutamate by activation of presynaptic nicotinic acetylcholine
receptors (nAChRs) is one of the most prevalent mechanism of nicotinic facilitation of …

Trk activation in the secretory pathway promotes Golgi fragmentation

…, MP Hudson, M Ko, P Philippidou, W Akmentin… - Molecular and Cellular …, 2010 - Elsevier
Activation of nascent receptor tyrosine kinases within the secretory pathway has been reported,
yet the consequences of intracellular activation are largely unexplored. We report that …