Furosemide was injected intravenously in anesthetized cats while the endocochlear potential
(EP) and tuning curves from fibers of the auditory nerve were simultaneously monitored in …

Many inner ear disorders cannot be adequately treated by systemic drug delivery. A blood-cochlear
barrier exists, similar physiologically to the blood-brain barrier, which limits the …

Numerous disease processes cause inner ear dysfunction and represent an opportunity for
therapeutic intervention. Hearing loss is the common endpoint of many inner ear disorders …

We have developed an automated, high-throughput behavioral screening method for detecting
hearing defects in zebrafish. Our assay monitors a rapid escape reflex in response to a …

The relation between the endocochlear potential and spontaneous discharge rate in
auditory nerve fibres was determined following intravenous injections of furosemide in …

Although the zebrafish has become an important model for genetic analysis of the vertebrate
auditory system, a comprehensive description of the zebrafish ear has been provided for …

Inner ear gene therapy using adeno-associated viral vectors (AAV) promises to alleviate
hearing and balance disorders. We previously established the benefits of Anc80L65 in targeting …

The anatomical and pharmacological inaccessibility of the inner ear is a major challenge in
drug-based treatment of auditory disorders. This also makes pharmacokinetic …

Rapid progress in understanding the molecular mechanisms associated with cochlear and
auditory nerve degenerative processes offers hope for the development of gene-transfer and …

In recent years studies on isolated hair cells have suggested that there is an inherent tuning
of hair cells determined by their mechanical and electrical properties. However, tuning for …