CNS myelin is strongly inhibitory to growing axons and is thought to be a major contributor to
CNS axon regenerative failure. Although a number of proteins present in myelin, including …

A novel neuronal receptor complex that mediates myelin's inhibitory action on nerve fiber
regeneration has at last been identified. This discovery could be an important step towards …

REFERAAT| De ecologische sleutelfactoren vormen een denkkader voor het uitvoeren van
een ecologische watersysteemanalyse. Ze geven inzicht in het ecologisch functioneren van …

LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic
function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA. Using …

Alzheimer's disease (AD) is a complex neurodegenerative disorder and is the most common
form of dementia in the elderly. Accumulating evidence in AD research suggests that …

Mutations of the mitochondrial PTEN (phosphatase and tensin homologue)‐induced kinase1
(PINK1) are important causes of recessive Parkinson disease (PD). Studies on loss of …

Inhibitors associated with CNS myelin are thought to be important in the failure of axons to
regenerate after spinal cord injury and in other neurodegenerative disorders. Here we show …

The POU transcription factor Oct-6, also known as SCIP or Tst-1, has been implicated as a
major transcriptional regulator in Schwann cell differentiation. Microscopic and …

Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well
established, fairly little is known about the molecular mechanisms affecting Aβ generation in …

Loss-of-function mutations in PARK2, the gene encoding the E3 ubiquitin ligase Parkin, are
the most frequent cause of recessive Parkinson's disease (PD). Parkin translocates from the …