[PDF][PDF] Prefrontal-subthalamic hyperdirect pathway modulates movement inhibition in humans
W Chen, C de Hemptinne, AM Miller, M Leibbrand… - Neuron, 2020 - cell.com
The ability to dynamically change motor outputs, such as stopping an initiated response, is
an important aspect of human behavior. A hyperdirect pathway between the inferior frontal …
an important aspect of human behavior. A hyperdirect pathway between the inferior frontal …
Cortical potentials evoked by subthalamic stimulation demonstrate a short latency hyperdirect pathway in humans
S Miocinovic, C de Hemptinne, W Chen… - Journal of …, 2018 - Soc Neuroscience
A monosynaptic projection from the cortex to the subthalamic nucleus is thought to have an
important role in basal ganglia function and in the mechanism of therapeutic subthalamic …
important role in basal ganglia function and in the mechanism of therapeutic subthalamic …
[HTML][HTML] The role of large-scale data infrastructure in developing next-generation deep brain stimulation therapies
Advances in neuromodulation technologies hold the promise of treating a patient’s unique
brain network pathology using personalized stimulation patterns. In service of these goals, …
brain network pathology using personalized stimulation patterns. In service of these goals, …
[HTML][HTML] Eight cylindrical contact lead recordings in the subthalamic region localize beta oscillations source to the dorsal STN
Background In Parkinson's disease (PD) patients, the subthalamic nucleus (STN) has prominent
oscillatory activity in the beta band, which may be related to the motor symptoms severity…
oscillatory activity in the beta band, which may be related to the motor symptoms severity…
[HTML][HTML] Prefrontal physiomarkers of anxiety and depression in Parkinson's disease
C de Hemptinne, W Chen, CA Racine… - Frontiers in …, 2021 - frontiersin.org
Objective: Anxiety and depression are prominent non-motor symptoms of Parkinson’s
disease (PD), but their pathophysiology remains unclear. We sought to understand their …
disease (PD), but their pathophysiology remains unclear. We sought to understand their …
Pallidal thermolesion unleashes gamma oscillations in the motor cortex in Parkinson's disease
…, DD Wang, S Miocinovic, W Chen… - Movement …, 2019 - Wiley Online Library
Background In Parkinson's disease, the emergence of motor dysfunction is thought to be
related to an imbalance between “antikinetic” and “prokinetic” patterns of oscillatory activity in …
related to an imbalance between “antikinetic” and “prokinetic” patterns of oscillatory activity in …
Local field potentials and ECoG
The ability to record human neural activity in the form of field potentials from deep brain
leads or surface brain electrodes has given us immense insight into the pathophysiology of …
leads or surface brain electrodes has given us immense insight into the pathophysiology of …
Altered prefrontal theta and gamma activity during an emotional face processing task in Parkinson disease
W Chen, C de Hemptinne, M Leibbrand… - Journal of cognitive …, 2019 - direct.mit.edu
Patients with Parkinson disease (PD) often experience nonmotor symptoms including
cognitive deficits, depression, and anxiety. Cognitive and affective processes are thought to be …
cognitive deficits, depression, and anxiety. Cognitive and affective processes are thought to be …
[BOOK][B] Prefrontal Cortical Modulation of Motor and Non-Motor Functions in Parkinson's Disease
W Chen - 2020 - search.proquest.com
The prefrontal cortex is involved in various cognitive and affective functions. In neuropsychiatric
conditions in which these functions are perturbed, such as Parkinson’s disease, …
conditions in which these functions are perturbed, such as Parkinson’s disease, …
AshwaMAX and Withaferin A inhibits gliomas in cellular and murine orthotopic models
E Chang, C Pohling, A Natarajan, TH Witney… - Journal of neuro …, 2016 - Springer
Glioblastoma multiforme (GBM) is an aggressive, malignant cancer Johnson and O’Neill (J
Neurooncol 107: 359–364, 2012 ). An extract from the winter cherry plant (Withania …
Neurooncol 107: 359–364, 2012 ). An extract from the winter cherry plant (Withania …