User profiles for Woong Sun

Woong Sun

Korea University
Verified email at korea.ac.kr
Cited by 9131

Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS

…, RR Buss, S Vinsant, D Prevette, W Sun… - Journal of …, 2006 - Soc Neuroscience
The death of cranial and spinal motoneurons (MNs) is believed to be an essential component
of the pathogenesis of amyotrophic lateral sclerosis (ALS). We tested this hypothesis by …

Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors

W Li, W Sun, Y Zhang, W Wei… - Proceedings of the …, 2011 - National Acad Sciences
Human embryonic stem cells (hESCs) hold enormous promise for regenerative medicine.
Typically, hESC-based applications would require their in vitro differentiation into a desirable …

Adaptive roles of programmed cell death during nervous system development

RR Buss, W Sun, RW Oppenheim - Annu. Rev. Neurosci., 2006 - annualreviews.org
The programmed cell death (PCD) of developing cells is considered an essential adaptive
process that evolved to serve diverse roles. We review the putative adaptive functions of PCD …

[HTML][HTML] Control of adult neurogenesis by programmed cell death in the mammalian brain

JR Ryu, CJ Hong, JY Kim, EK Kim, W Sun, SW Yu - Molecular brain, 2016 - Springer
The presence of neural stem cells (NSCs) and the production of new neurons in the adult
brain have received great attention from scientists and the public because of implications to …

[PDF][PDF] Drp1-Zip1 interaction regulates mitochondrial quality surveillance system

…, B Cho, HC Kang, SW Yu, SJ Yoo, H Kim, W Sun - Molecular cell, 2019 - cell.com
Mitophagy, a mitochondrial quality control process for eliminating dysfunctional mitochondria,
can be induced by a response of dynamin-related protein 1 (Drp1) to a reduction in …

Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson's disease modeling

…, HS Je, HH Ng, J Kwon, NH Kim, KH Hong, W Sun… - Stem …, 2020 - academic.oup.com
Recent studies have demonstrated the generation of midbrain-like organoids (MOs) from
human pluripotent stem cells. However, the low efficiency of MO generation and the relatively …

[HTML][HTML] ACT-PRESTO: Rapid and consistent tissue clearing and labeling method for 3-dimensional (3D) imaging

…, SJ Jeong, C Moon, Y Choe, IJ Rhyu, H Kim, W Sun - Scientific reports, 2016 - nature.com
Understanding the structural organization of organs and organisms at the cellular level is a
fundamental challenge in biology. This task has been approached by reconstructing three-…

Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax

W Sun, A Winseck, S Vinsant, O Park… - Journal of …, 2004 - Soc Neuroscience
In the dentate gyrus (DG) of the adult mouse hippocampus, a substantial number of new
cells are generated daily, but only a subset of these survive and differentiate into mature …

[HTML][HTML] Physiological and pathological significance of dynamin-related protein 1 (drp1)-dependent mitochondrial fission in the nervous system

…, SY Choi, HM Cho, HJ Kim, W Sun - Experimental …, 2013 - ncbi.nlm.nih.gov
Mitochondria are essential for proper neuronal morphogenesis and functions, as they are the
major source of energy for neural development. The dynamic morphology of mitochondria …

[HTML][HTML] Exosome engineering for efficient intracellular delivery of soluble proteins using optically reversible protein–protein interaction module

…, S Lee, H Choi, J Kim, MR Shaker, W Sun… - Nature …, 2016 - nature.com
Nanoparticle-mediated delivery of functional macromolecules is a promising method for
treating a variety of human diseases. Among nanoparticles, cell-derived exosomes have …