Axonal transport defects in neurodegenerative diseases
Adult-onset neurodegenerative diseases (AONDs) comprise a heterogeneous group of
neurological disorders characterized by a progressive, age-dependent decline in neuronal …
neurological disorders characterized by a progressive, age-dependent decline in neuronal …
[HTML][HTML] Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)
Y Atagi, CC Liu, MM Painter, XF Chen… - Journal of Biological …, 2015 - ASBMB
Several heterozygous missense mutations in the triggering receptor expressed on myeloid
cells 2 (TREM2) have recently been linked to risk for a number of neurological disorders …
cells 2 (TREM2) have recently been linked to risk for a number of neurological disorders …
Soluble TREM2 induces inflammatory responses and enhances microglial survival
…, X Li, L Wu, L Jia, H Zheng, M Painter, Y Atagi… - Journal of Experimental …, 2017 - rupress.org
Triggering receptor expressed on myeloid cells 2 (TREM2) is an innate immune receptor
expressed in microglia in the brain. A soluble form of TREM2 (sTREM2) derived from proteolytic …
expressed in microglia in the brain. A soluble form of TREM2 (sTREM2) derived from proteolytic …
Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer's disease patients and controls
E Martínez-Morillo, O Hansson, Y Atagi, G Bu… - Acta …, 2014 - Springer
The apolipoprotein E (ApoE) ε4 allele is the strongest risk factor of sporadic Alzheimer’s
disease (AD), however, the fluid concentrations of ApoE and its different isoforms (ApoE2, …
disease (AD), however, the fluid concentrations of ApoE and its different isoforms (ApoE2, …
[HTML][HTML] TREM2 in CNS homeostasis and neurodegenerative disease
MM Painter, Y Atagi, CC Liu, R Rademakers… - Molecular …, 2015 - Springer
Myeloid-lineage cells accomplish a myriad of homeostatic tasks including the recognition of
pathogens, regulation of the inflammatory milieu, and mediation of tissue repair and …
pathogens, regulation of the inflammatory milieu, and mediation of tissue repair and …
[HTML][HTML] LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways
L Yang, CC Liu, H Zheng, T Kanekiyo, Y Atagi… - Journal of …, 2016 - Springer
Background Neuroinflammation is characterized by microglial activation and the increased
levels of cytokines and chemokines in the central nervous system (CNS). Recent evidence …
levels of cytokines and chemokines in the central nervous system (CNS). Recent evidence …
Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation
H Zheng, CC Liu, Y Atagi, XF Chen, L Jia, L Yang… - Neurobiology of …, 2016 - Elsevier
… Rosenberry and Yuka Atagi provided technical assistance. Lin Jia and Longyu Yang
contributed to the preparation of the figures. Guojun Bu and Xiao-Fen Chen revised the article. …
contributed to the preparation of the figures. Guojun Bu and Xiao-Fen Chen revised the article. …
Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer's disease
…, M DeTure, Y Yamazaki, M Tachibana, Y Atagi… - Acta …, 2016 - Springer
Cerebral amyloid angiopathy (CAA) often coexists with Alzheimer’s disease (AD). APOE4 is
a strong genetic risk factor for both AD and CAA. Sex-dependent differences have been …
a strong genetic risk factor for both AD and CAA. Sex-dependent differences have been …
[HTML][HTML] Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells
Background Pallido-ponto-nigral degeneration (PPND), a major subtype of frontotemporal
dementia with parkinsonism related to chromosome 17 (FTDP-17), is a progressive and …
dementia with parkinsonism related to chromosome 17 (FTDP-17), is a progressive and …
[HTML][HTML] Apolipoprotein E inhibits cerebrovascular pericyte mobility through a RhoA protein-mediated pathway
CS Casey, Y Atagi, Y Yamazaki, M Shinohara… - Journal of Biological …, 2015 - ASBMB
Pericytes play a critical role in the cerebrovasculature within the CNS. These small contractile
cells produce large quantities of apolipoprotein E (apoE) whose isoforms influence …
cells produce large quantities of apolipoprotein E (apoE) whose isoforms influence …