The development of sensitive and versatile techniques to detect protein-protein interactions
in vivo is important for understanding protein functions. The previously described techniques…

Microglia maintain homeostasis in the brain, but whether aberrant microglial activation can
cause neurodegeneration remains controversial. Here, we use transcriptome profiling to …

Autosomal dominant mutations of the RNA/DNA binding protein FUS are linked to familial
amyotrophic lateral sclerosis (FALS); however, it is not clear how FUS mutations cause …

Recent advances in the genetics of amyotrophic lateral sclerosis (ALS) have provided key
mechanistic insights to the pathogenesis of this devastating neurodegenerative disease. …

Pathogenic bacterial effectors suppress pathogen-associated molecular pattern (PAMP)-triggered
host immunity, thereby promoting parasitism. In the presence of cognate resistance …

Persistent accumulation of misfolded proteins causes endoplasmic reticulum (ER) stress, a
prominent feature in many neurodegenerative diseases including amyotrophic lateral …

Neural circuits involving midbrain dopaminergic (DA) neurons regulate reward and goal-directed
behaviors. Although local GABAergic input is known to modulate DA circuits, the …

Several critical events dictate the successful establishment of nascent vasculature in yolk
sac and in the developing embryos. These include aggregation of angioblasts to form the …

Trophic factor signaling is important for the migration, differentiation, and survival of enteric
neurons during development. The mechanisms that regulate the maturation of enteric …

NMDA receptors are critical for neuronal communication. Dysfunction in NMDA receptors
has been implicated in neuropsychiatric diseases. While it is well recognized that the …