Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
In this study, we report the isolation from canine intestines of 2-arachidonyl glycerol (2-Ara-Gl).
Its structure was determined by mass spectrometry and by direct comparison with a …
Its structure was determined by mass spectrometry and by direct comparison with a …
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
…, E Fride, A Breuer, Z Vogel… - Proceedings of the …, 2001 - National Acad Sciences
… Thus, after silylation with bis(trimethylsilyl)- trifluoroacetamide, we observed a strong peak
at m/z 219 typical for the glyceryl di(trimethylsilyl) moiety (m/z = 218 + 1) and a peak at m/z 508…
at m/z 219 typical for the glyceryl di(trimethylsilyl) moiety (m/z = 218 + 1) and a peak at m/z 508…
An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
2-Arachidonoyl-glycerol (2-Ara-Gl) has been isolated from various tissues and identified as
an endogenous ligand for both cannabinoid receptors, CB 1 and CB 2 . Here we report that …
an endogenous ligand for both cannabinoid receptors, CB 1 and CB 2 . Here we report that …
[HTML][HTML] Modulation of astrocyte activity by cannabidiol, a nonpsychoactive cannabinoid
… Ewa Kozela wrote the article; Ana Juknat and Zvi Vogel contributed to discussions of the
article content, and to reviewing and editing the manuscript before submission. …
article content, and to reviewing and editing the manuscript before submission. …
Anandamide, a brain endogenous compound, interacts specifically with cannabinoid receptors and inhibits adenylate cyclase
A putative endogenous cannabinoid ligand, arachidonylethanolamide (termed “anandamide”),
was isolated recently from porcine brain. Here we demonstrate that this compound is a …
was isolated recently from porcine brain. Here we demonstrate that this compound is a …
Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular" cross-talk" between G-protein-linked receptors.
We have tested the hypothesis that guanine-nucleotide-binding-protein-coupled receptors
may be able to interact with each other at a molecular level. To address this question, we …
may be able to interact with each other at a molecular level. To address this question, we …
[HTML][HTML] N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol …
Background Microglia provide continuous immune surveillance of the CNS and upon activation
rapidly change phenotype to express receptors that respond to chemoattractants during …
rapidly change phenotype to express receptors that respond to chemoattractants during …
Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor
In order to establish the structural requirements for binding to the brain cannabinoid receptor
(CB 1 ), we have synthesized numerous fatty acid amides, ethanolamides, and some …
(CB 1 ), we have synthesized numerous fatty acid amides, ethanolamides, and some …
[HTML][HTML] Cannabinoids Δ9-tetrahydrocannabinol and cannabidiol differentially inhibit the lipopolysaccharide-activated NF-κB and interferon-β/STAT proinflammatory …
Cannabinoids have been shown to exert anti-inflammatory activities in various in vivo and
in vitro experimental models as well as ameliorate various inflammatory degenerative …
in vitro experimental models as well as ameliorate various inflammatory degenerative …
Inhibition of adenylyl cyclase isoforms V and VI by various Gβγ subunits
…, T Pfeuffer, I Nevo, WF Simonds, Z Vogel - The FASEB …, 1998 - Wiley Online Library
… AC activity can be stimulated by Gas and is inhibited by Gai/z. It has recently been shown
that the wide array of AC isoforms (nine are currently known) display differential sensitivity to …
that the wide array of AC isoforms (nine are currently known) display differential sensitivity to …