Cellular Strategies of Axonal Pathfinding
- 1Departments of Neurosciences, and Cell and Developmental Biology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104-6058
- 2Departments of Pathology and Cell Biology, Neuroscience, and Ophthalmology, Columbia University, College of Physicians and Surgeons, New York, New York 10032
- Correspondence: cam4{at}columbia.edu and raperj{at}mail.med.upenn.edu
Abstract
Axons follow highly stereotyped and reproducible trajectories to their targets. In this review we address the properties of the first pioneer neurons to grow in the developing nervous system and what has been learned over the past several decades about the extracellular and cell surface substrata on which axons grow. We then discuss the types of guidance cues and their receptors that influence axon extension, what determines where cues are expressed, and how axons respond to the cues they encounter in their environment.
Footnotes
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Editors: Marc Tessier-Lavigne and Alex L. Kolodkin
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Additional Perspectives on Neuronal Guidance available at www.cshperspectives.org
- Copyright © 2010 Cold Spring Harbor Laboratory Press; all rights reserved
